Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy.

Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including:

In vivo studies with standard and alternative species

In vitro studies and alternative methodologies

Molecular, biochemical, and cellular techniques

Pharmacokinetics and pharmacodynamics

Mathematical modeling and computer programs

Forensic analyses

Risk assessment

Data collection and analysis.